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Iressa ®
Iressa ®, gefitinib, ZD-1839 Discovery: Zeneca (UK) WO/1996/016960 US approval: May 2003 Label change: June 2005 FDA has approved new labeling for Iressa that states the medicine should be used only in...
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Tarceva ®
Tarceva ®, erlotinib hydrochloride, OSI-774 Discovery: Pfizer WO/1996/30347. Pfizer turned over the rights to OSI to meet U.S. FTC requirements related to Pfizer’s merger with Warner-Lambert in June...
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Nexavar ®
Nexavar ®, sorafenib tosylate, BAY-439006 Discovery: Bayer WO/2000/042012 US Approval: December 2005 wiki; Org.Proc.Res.Dev. ’02, 777 PDB: 1UWH; 1UWJ; 2HZN
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Sutent ®
Sutent ®, sunititnib malate, SU11248 Discovery: Sugen: Provisional filed February 15, 2000 WO/2001/060814. Sugen was bought by Pharmacia-Upjohn which in turn merged with Pfizer. US Approval: January...
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Sprycel ®
Sprycel ®, dasatinib, BMS-354825 Discovery: Bristol-Myers Squibb WO/2000/062778 US Approval: June 2006 wiki; PDB: 2GQG; FDA; J Med Chem ’06 6819; Named after its inventor?
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Tykerb ®
Tykerb ®, lapatinib, GW-572016 Discovery: Glaxo UK: WO/1999/35146 US Approval: March 2007 wiki; fda; PDB: 1XKK; Nature Reviews Drug Discovery
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Kinase Inhibitors: On the market
Nothing new to see here, but its about time I got around to it. Here are the currently approved small molecule kinase inhibitors, with a few quick facts and links for each. Xcovery’s got what they’re...
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$
So what are they worth? TotallyMedicinal’s got the low-low. TY TM for data: mirrored here.
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Tasigna Approved
aka nilotinib, AMN-107 is a Novartis‘ follow-on to Gleevec now approved for CML. wiki; clinic; WO/2002/022597
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Toceranib
aka Palladia, PHA-291639, & SU11654 got its FDA Approval today! Well… In dogs at least:. It’s for canine mast cell tumors. yeh, its the pyrrolidine version of Sutent & its the phosphate salt...
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